flaA mRNA transcription level correlates with Helicobacter pylori colonisation efficiency in gnotobiotic piglets
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چکیده
منابع مشابه
Motility as a factor in the colonisation of gnotobiotic piglets by Helicobacter pylori.
Non-motile variants of Helicobacter pylori (strain 26695) occurred with a frequency of 1.6 (SD 0.4) x 10(-4) variants/cell/division cycle, and reversion to the motile form occurred with a frequency of less than 10(-7) variants/cell/division cycle. The two forms remained greater than 90% pure for up to 50 cell divisions and differed only in the presence or absence of motility and flagella. Bacte...
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Gnotobiotic piglets infected with Helicobacter pylori were treated with various antimicrobials as monotherapy and dual therapy, and the results were compared to those for piglets treated with a triple-therapy regimen (bismuth subsalicyclate at 5.7 mg/kg of body weight, metronidazole at 4.4 mg/kg, and amoxicillin at 6.8 mg/kg four times a day [QID]). Clearance of infection was assessed after 7 d...
متن کاملCampylobacter pylori virulence factors in gnotobiotic piglets.
Thirty-three gnotobiotic piglets from four litters were challenged with motile and nonmotile strains of Campylobacter pylori. The most motile strain, 26695, was the most virulent, with a 100% infection rate. The least motile strain, Tx30a, was the least virulent, with an infection rate of only 17%. Strain 60190 was weakly motile and had intermediate virulence, with an infection rate of 40%. Str...
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To investigate the role of the Helicobacter pylori cytotoxin in the pathogenesis of gastritis, gnotobiotic piglets were colonized with either toxigenic H. pylori or a nontoxigenic isogenic mutant. Only piglets given the toxigenic strain developed toxin-neutralizing antibodies (indicating that toxin is expressed in vivo), but there was no difference in bacterial colonization, epithelial vacuolat...
متن کاملAntigenic and immunogenic evaluation of Helicobacter pylori FlaA epitopes
Objective(s): Helicobacter pyloriare among most common human pathogens affecting at least half of the world’s population. Mobility is one of the important primary factors in bacterial colonization and invasion. The purpose of this research is cloning, expression, and purification of FlaA protein specific epitopes in order to evaluate their antigenicity and immunogenicity. Materials and Methods:...
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ژورنال
عنوان ژورنال: Journal of Medical Microbiology
سال: 1999
ISSN: 0022-2615,1473-5644
DOI: 10.1099/00222615-48-4-395